rs3764352

This is a regulatory region variant variant in the PPP1R1B gene.

▶

GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

age at initiation of smoking

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele T
OR 0.01
p 4.0e-9
N 618,541
Large GWAS
European
▶

Research that mentions this SNP (1)

▶
Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European‐ and African‐American smokers
AssociationN=2,037Joke Beuten et al.(2007)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Association analysis of 6 SNPs within the PPP1R1B gene (DARPP-32) in 602 nuclear families found that in European-Americans, a C-T-G-C haplotype formed by rs2271309-rs907094-rs3764352-rs3817160 was significantly associated with smoking quantity (Z=2.50, P=0.01). This represents the first evidence for PPP1R1B involvement in nicotine dependence susceptibility.

Traits studied:Fagerstrom Test for Nicotine DependenceHeaviness of smoking indexNicotine dependenceSmoking quantity
PubMedDOIMetascience Observatory

About PPP1R1B

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

View all PPP1R1B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…