PPP1R1B

protein phosphatase 1 regulatory inhibitor subunit 1B

Summary

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Known Variants16 total

rsidPosition (GRCh37)AllelesClassClinVar
rs479539017:37,781,610G/Cupstream gene variant
rs87960617:37,781,849A/Gupstream gene variant
rs36754317817:37,783,717G/Anot provided
rs36754317917:37,785,427G/Anot provided
rs1260193017:37,789,432C/Tupstream gene variant
rs254587350117:37,790,204G/Auncertain significance
rs77417334117:37,790,271A/Guncertain significance
rs36754318017:37,790,287G/Anot provided
rs75759268517:37,790,337C/Auncertain significance
rs90709417:37,790,371G/Aupstream gene variant
rs376435217:37,790,939C/Tregulatory region variant
rs14240505917:37,791,880G/Auncertain significance
rs3425741417:37,791,894A/Gbenign
rs36754318117:37,791,907C/Anot provided
rs20146860317:37,791,916C/Guncertain significance
rs7949706917:37,792,096C/Abenign

Gene information from NCBI Gene. Variant classifications from ClinVar.