rs879606

This is a upstream gene variant variant in the PPP1R1B gene.

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Research that mentions this SNP (1)

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Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European‐ and African‐American smokers
AssociationN=2,037Joke Beuten et al.(2007)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Association analysis of 6 SNPs within the PPP1R1B gene (DARPP-32) in 602 nuclear families found that in European-Americans, a C-T-G-C haplotype formed by rs2271309-rs907094-rs3764352-rs3817160 was significantly associated with smoking quantity (Z=2.50, P=0.01). This represents the first evidence for PPP1R1B involvement in nicotine dependence susceptibility.

Traits studied:Fagerstrom Test for Nicotine DependenceHeaviness of smoking indexNicotine dependenceSmoking quantity
PubMedDOIMetascience Observatory

About PPP1R1B

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

View all PPP1R1B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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