rs3775194

This is a intron variant variant in the VEGFC gene.

▶

Research that mentions this SNP (1)

▶
Role ofVEGF-CGene Polymorphisms in Susceptibility to Hepatocellular Carcinoma and Its Pathological Development
AssociationN=655Ming-Chang Hsieh et al.(2014)· Journal of Clinical Laboratory Analysis

This case-control study of 135 HCC patients and 520 controls examined five VEGF-C gene polymorphisms and found that the rs1485766 A/A genotype significantly increased HCC risk (OR=2.012, P=0.021). Additionally, rs7664413 CT/TT genotypes were associated with advanced tumor stage (P=0.0027), and four haplotypes (GGACA, GACTG, CGATG, GGCTG) of these five SNPs showed significant associations with HCC susceptibility.

Traits studied:HCC susceptibilityHepatocellular carcinomaLiver cirrhosisTumor stage
PubMedDOIMetascience Observatory

About VEGFC

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]

View all VEGFC variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…