VEGFC
vascular endothelial growth factor C
Summary
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]
Known Variants65 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs370007298 | 4:177,605,173 | C/T | — | likely benign |
| rs370465436 | 4:177,605,184 | G/A | — | conflicting classifications of pathogenicity |
| rs17697305 | 4:177,606,651 | T/C | intron variant | — |
| rs13142168 | 4:177,608,064 | T/A | — | benign |
| rs2110962728 | 4:177,608,363 | T/G | — | benign |
| rs186096619 | 4:177,608,422 | G/C | — | uncertain significance |
| rs575984035 | 4:177,608,494 | T/G | — | uncertain significance |
| rs745769667 | 4:177,608,505 | T/G | — | uncertain significance |
| rs768802006 | 4:177,608,512 | G/A | — | benign |
| rs202208990 | 4:177,608,534 | C/A | — | uncertain significance |
| rs2477059409 | 4:177,608,573 | C/A | — | uncertain significance |
| rs745847895 | 4:177,608,606 | C/A | — | uncertain significance |
| rs564667848 | 4:177,608,626 | T/C | — | uncertain significance |
| rs7664413 | 4:177,608,707 | C/T | intron variant | — |
| rs4604006 | 4:177,608,775 | T/C | — | benign |
| rs4529000 | 4:177,608,875 | A/C | — | benign |
| rs200182587 | 4:177,608,981 | C/T | — | conflicting classifications of pathogenicity |
| rs1219630611 | 4:177,609,005 | C/T | — | likely benign |
| rs2477061005 | 4:177,609,071 | C/T | — | uncertain significance |
| rs13136065 | 4:177,609,203 | G/A | — | benign |
| rs2877962 | 4:177,609,259 | C/T | — | benign |
| rs2333495 | 4:177,609,264 | C/T | — | benign |
| rs1485766 | 4:177,610,884 | T/A | — | — |
| rs11947611 | 4:177,611,397 | G/C | — | — |
| rs371162363 | 4:177,614,117 | G/A | — | — |
| rs3775194 | 4:177,623,877 | C/G | intron variant | — |
| rs200933230 | 4:177,632,698 | T/C | — | uncertain significance |
| rs2477118973 | 4:177,632,713 | A/T | — | uncertain significance |
| rs377096543 | 4:177,632,728 | C/T | — | benign |
| rs587777567 | 4:177,632,729 | G/A | stop gained | pathogenic |
| rs538678541 | 4:177,632,752 | C/T | — | uncertain significance |
| rs770761859 | 4:177,632,785 | G/C | — | benign |
| rs587777566 | 4:177,632,785 | — | — | pathogenic |
| rs774139549 | 4:177,632,786 | G/C | — | benign |
| rs928660549 | 4:177,632,799 | A/C | — | uncertain significance |
| rs370267488 | 4:177,632,819 | C/A | — | benign |
| rs12500029 | 4:177,637,600 | G/T | — | — |
| rs580893 | 4:177,637,830 | T/C | intron variant | — |
| rs585706 | 4:177,648,664 | T/C | — | benign |
| rs1734896876 | 4:177,648,960 | T/A | — | uncertain significance |
| rs372307330 | 4:177,648,983 | A/G | — | likely benign |
| rs375274193 | 4:177,648,989 | G/A | — | likely benign |
| rs767851455 | 4:177,649,109 | C/G | — | uncertain significance |
| rs202135883 | 4:177,649,120 | T/C | — | benign |
| rs1057524647 | 4:177,649,124 | T/A | — | pathogenic |
| rs1230115284 | 4:177,650,714 | C/T | — | uncertain significance |
| rs373436555 | 4:177,650,735 | C/G | — | uncertain significance |
| rs539876211 | 4:177,650,849 | C/T | — | uncertain significance |
| rs893547563 | 4:177,650,855 | T/C | — | uncertain significance |
| rs41278571 | 4:177,650,866 | C/T | — | benign |
| rs200219952 | 4:177,650,876 | C/T | — | conflicting classifications of pathogenicity |
| rs374947493 | 4:177,650,909 | G/A | — | likely benign |
| rs375440489 | 4:177,650,910 | A/G | — | likely benign |
| rs6838834 | 4:177,653,598 | C/A | — | — |
| rs6552191 | 4:177,680,817 | A/C | — | — |
| rs4557213 | 4:177,689,133 | G/A | intron variant | — |
| rs13107976 | 4:177,695,072 | C/G | — | — |
| rs113990608 | 4:177,705,260 | C/T | intron variant | — |
| rs4571283 | 4:177,705,862 | G/A | intron variant | — |
| rs3755972 | 4:177,712,975 | C/T | regulatory region variant | — |
| rs55728985 | 4:177,713,326 | T/A | — | benign |
| rs1209217872 | 4:177,713,405 | C/G | — | uncertain significance |
| rs368168133 | 4:177,713,407 | G/A | — | uncertain significance |
| rs772623279 | 4:177,713,430 | A/T | — | benign |
| rs768189031 | 4:177,713,449 | A/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.