rs7664413

This is a intron variant variant in the VEGFC gene.

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Research that mentions this SNP (1)

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Role ofVEGF-CGene Polymorphisms in Susceptibility to Hepatocellular Carcinoma and Its Pathological Development
AssociationN=655Ming-Chang Hsieh et al.(2014)· Journal of Clinical Laboratory Analysis

This case-control study of 135 HCC patients and 520 controls examined five VEGF-C gene polymorphisms and found that the rs1485766 A/A genotype significantly increased HCC risk (OR=2.012, P=0.021). Additionally, rs7664413 CT/TT genotypes were associated with advanced tumor stage (P=0.0027), and four haplotypes (GGACA, GACTG, CGATG, GGCTG) of these five SNPs showed significant associations with HCC susceptibility.

Traits studied:HCC susceptibilityHepatocellular carcinomaLiver cirrhosisTumor stage
PubMedDOIMetascience Observatory

About VEGFC

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]

View all VEGFC variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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