rs41278571

This variant is located in the VEGFC gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

vascular endothelial growth factor C level

Gudjonsson A et al. “A genome-wide association study of serum proteins reveals shared loci with common diseases.” Nature Communications 13(1):480 (2022)

Allele T

OR 2.00

p 5.0e-240

N 5,361

Large GWAS

European

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)

Allele T

OR 1.74

p 1.0e-46

N 3,301

Large GWAS

European

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ClinVar annotation

Benign★★★☆

2 submitters

Lymphatic malformation 4; not provided

View on ClinVar →

About VEGFC

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]

View all VEGFC variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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