rs3785234

This variant is located in the RBFOX1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

wellbeing measurement

Baselmans BML et al. “Multivariate genome-wide analyses of the well-being spectrum.” Nature Genetics 51(3):445-451 (2019)
Allele T
OR 0.01
p 2.0e-14
N 2,083,151
Large GWAS
European

depressive symptom measurement

Turley P et al. “Multi-trait analysis of genome-wide association summary statistics using MTAG.” Nature Genetics 50(2):229-237 (2018)
Allele T
OR 0.01
p 5.0e-9
N 354,862
Large GWAS
European

major depressive disorder

Li X et al. “Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder.” Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 43(10):2146-2153 (2018)
Allele T
OR 1.03
p 2.0e-8
N 336,753
Large GWAS
multi-ancestry

About RBFOX1

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

View all RBFOX1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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