rs3788862

This variant is located in the MAOA gene.

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Research that mentions this SNP (1)

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Aggressive behavior, related conduct problems, and variation in genes affecting dopamine turnover
AssociationN=421Elena L. Grigorenko et al.(2010)· Aggressive Behavior

This study investigated 12 genetic polymorphisms in four dopamine-related genes (COMT, MAOA, MAOB, and DBH) in 179 incarcerated male Russian adolescents and 242 matched controls to identify genetic associations with aggressive behavior and conduct disorder. The authors found that while individual genetic variants did not differentiate groups, specific combinations of variants (haplotypes) and interactions between variants within and across genes produced informative classifications for incarceration status (P < 0.0001, Nagelkerke R² = 0.141) and conduct disorder diagnosis (P < 0.0001, Nagelkerke R² = 0.158), with a 4-marker model involving COMT rs737865, COMT rs165599, DBH rs1611115, and DBH rs739398 being most predictive.

Traits studied:Aggressive behaviorConduct disorderIncarceration statusViolent criminal behavior
PubMedDOIMetascience Observatory

About MAOA

This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

View all MAOA variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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