rs379464

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

complement C4 measurement

Borbye-Lorenzen N et al. “The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders.” Cell Genomics 3(12):100457 (2023)
Allele T
OR 0.20
p 3.0e-52
N 68,768
Large GWAS
European
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Research that mentions this SNP (1)

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Prognostic value of Notch receptors in postsurgical patients with hepatitis B virus‐related hepatocellular carcinoma
AssociationN=465Tingdong Yu et al.(2017)· Cancer Medicine

Candidate gene study of 465 HBV-related hepatocellular carcinoma (HCC) patients examined 19 SNPs in Notch pathway receptors (NOTCH1-4) using Sanger sequencing. Four SNPs significantly associated with overall survival: rs1043996 (NOTCH3), rs422951 (NOTCH4), rs520692 (NOTCH4), and rs3830041 (NOTCH4). Notch3 mRNA was significantly elevated in tumors (P<0.0001) and higher expression predicted poorer overall and recurrence-free survival.

Traits studied:Hepatocellular carcinoma (HBV-related)Overall survivalRecurrence-free survival
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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