rs380286
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
basal cell carcinoma
Adolphe C et al. “Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility.” Genome Medicine 13(1):19 (2021)
Allele A
OR 0.16
p 8.0e-48
N 392,871
Large GWAS
European
lung cancer, family history of lung cancer
Gabriel AAG et al. “Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden.” Journal of the National Cancer Institute 114(8):1159-1166 (2022)
Allele A
OR 0.88
p 5.0e-42
N 329,946
Large GWAS
European
lung carcinoma
McKay JD et al. “Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.” Nature Genetics 49(7):1126-1132 (2017)
Allele G
OR 1.15
p 2.0e-32
N 85,716
Large GWAS
European
Hung RJ et al. “Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5(p)15.33 TERT-CLPTM1Ll Region.” Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer 14(8):1360-1369 (2019)
Allele G
OR 1.30
p 4.0e-16
N 8,031
Large GWAS
European
cutaneous melanoma, hair color
Landi MT et al. “Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility.” Nature Genetics 52(5):494-504 (2020)
Allele G
OR —
p 5.0e-24
N 764,610
Large GWAS
European
lung adenocarcinoma
Hung RJ et al. “Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5(p)15.33 TERT-CLPTM1Ll Region.” Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer 14(8):1360-1369 (2019)
Allele A
OR 1.33
p 2.0e-14
N 7,192
Large GWAS
European
head and neck carcinoma, lung cancer
Guo H et al. “A genome-wide cross-cancer meta-analysis highlights the shared genetic links of five solid cancers.” Frontiers in Microbiology 14:1116592 (2023)
Allele G
OR —
p 3.0e-12
N 32,634
Meta-analysisLarge GWAS
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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