rs3826656

This is a upstream gene variant variant in the CD33 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

blood protein amount

Orrù V et al. “Complex genetic signatures in immune cells underlie autoimmunity and inform therapy.” Nature Genetics 52(10):1036-1045 (2020)
Allele A
OR 0.46
p 9.0e-30
N 1,554
Large GWAS
European
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Research that mentions this SNP (1)

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Replication study of genome‐wide associated SNPs with late‐onset Alzheimer's disease
AssociationN=1,969Burns LC et al.(2011)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This is a replication study of 12 SNPs previously associated with late-onset Alzheimer's disease (LOAD) in a large case-control sample of 993 Caucasian American cases and 976 controls. The primary analysis found no statistically significant associations between the 12 SNPs and AD risk. However, the study identified two novel associations: rs16934131 in KCNMA1 was significantly associated with age-at-onset (p=0.0066) and disease duration (p=0.0002), while rs3746319 in ZNF224 was associated with age-at-onset (p=0.002).

Traits studied:Age-at-onset of Alzheimer's diseaseDisease duration of Alzheimer's diseaseLate-onset Alzheimer's disease
PubMedDOIMetascience Observatory

About CD33

Enables protein phosphatase binding activity; protein tyrosine phosphatase activator activity; and sialic acid binding activity. Involved in several processes, including immune response-regulating signaling pathway; negative regulation of cytokine production; and negative regulation of monocyte activation. Located in Golgi apparatus; external side of plasma membrane; and peroxisome. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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