rs3865314

This variant is located in the NPEPPS gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

dentures

Shungin D et al. “Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.” Nature Communications 10(1):2773 (2019)

Allele A

OR 0.03

p 7.0e-9

N 461,031

Large GWAS

European

dental caries, dentures

Shungin D et al. “Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.” Nature Communications 10(1):2773 (2019)

Allele A

OR 0.01

p 1.0e-8

N 487,823

Large GWAS

multi-ancestry

testosterone measurement

Harrison S et al. “Testosterone and socioeconomic position: Mendelian randomization in 306,248 men and women in UK Biobank.” Science Advances 7(31) (2021)

Allele C

OR —

β 0.000

p 2.0e-8

N 158,000

Major Consortium StudyLarge GWAS

European

About NPEPPS

This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]