NPEPPS

aminopeptidase puromycin sensitive

Summary

This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]

Known Variants63 total

rsidPosition (GRCh37)AllelesClassClinVar
rs6207396517:45,599,591T/A
rs293518317:45,607,572T/A
rs807748517:45,608,326A/Cregulatory region variant
rs250886024117:45,608,704G/Tuncertain significance
rs190774636517:45,608,710T/Cuncertain significance
rs190775192917:45,608,748G/Clikely benign
rs250886040317:45,608,751T/Clikely benign
rs77887833817:45,608,775C/Tuncertain significance
rs20006587917:45,608,784C/Tbenign
rs20121239017:45,608,885C/Tlikely benign
rs75262374817:45,608,920A/Guncertain significance
rs6207396817:45,609,270T/Gregulatory region variant
rs54925805617:45,609,550C/T
rs807982117:45,611,704T/A
rs1186973017:45,614,763T/G
rs7747821217:45,615,649C/T
rs14997212717:45,615,666C/Tintron variant
rs479428717:45,617,505T/Gregulatory region variant
rs1245176617:45,621,261A/C
rs99578104017:45,623,268C/Tlikely benign
rs479437217:45,627,760G/T
rs3604320017:45,629,406G/Aintron variant
rs998946617:45,635,239C/Tdownstream gene variant
rs1186805817:45,640,405G/Tintron variant
rs15131559417:45,649,397T/Cintron variant
rs1260329017:45,650,196T/Cintron variant
rs53890310617:45,651,768T/A
rs807710617:45,653,291T/Gintron variant
rs14141571917:45,654,184G/Aintron variant
rs123638698917:45,660,189A/Guncertain significance
rs1044537417:45,662,383T/A
rs76344589217:45,662,890C/Tuncertain significance
rs214385292017:45,663,032T/Cuncertain significance
rs37218765717:45,664,605A/Gbenign
rs14582904217:45,664,686A/Gbenign
rs261186717:45,664,861A/G
rs11795261617:45,666,998T/Cintron variant
rs20094822917:45,668,075G/Cbenign
rs76654476617:45,668,204G/Auncertain significance
rs137450212917:45,668,242A/Guncertain significance
rs6207401417:45,668,509A/Gintron variant
rs77410990117:45,669,416T/Cuncertain significance
rs386531417:45,669,524A/T
rs479383617:45,670,312G/Aintron variant
rs20009583717:45,673,812A/Guncertain significance
rs807210017:45,674,687A/Tintron variant
rs37017021317:45,677,045G/Auncertain significance
rs250881336117:45,679,037C/Guncertain significance
rs143259666917:45,679,078G/Auncertain significance
rs250881873417:45,681,308C/Tuncertain significance
rs36871201417:45,681,320A/Tuncertain significance
rs78048942717:45,682,828A/Guncertain significance
rs11720187417:45,688,849G/Tintron variant
rs36865825217:45,689,888G/Auncertain significance
rs37501238317:45,689,909C/Tuncertain significance
rs14508230717:45,691,031G/Tbenign
rs250883885717:45,691,039A/Tuncertain significance
rs37337388317:45,695,764G/Auncertain significance
rs36891364617:45,695,773G/Auncertain significance
rs720754217:45,697,549C/A
rs3459846417:45,699,143G/Cuncertain significance
rs20184207917:45,699,261G/Auncertain significance
rs76710198017:45,699,830T/C

Gene information from NCBI Gene. Variant classifications from ClinVar.