rs3891585
This is a intron variant variant in the MEIS1 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
PR interval
Ntalla I et al. “Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.” Nature Communications 11(1):2542 (2020)
Allele A
OR 1.35
p 8.0e-96
N 292,566
Large GWAS
multi-ancestry
Butler AM et al. “Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.” Circulation. Cardiovascular Genetics 5(6):639-46 (2012)
Allele A
OR 2.13
p 1.0e-11
N 13,415
Large GWAS
African American or Afro-Caribbean
facial morphology trait
White JD et al. “Insights into the genetic architecture of the human face.” Nature Genetics 53(1):45-53 (2021)
Allele A
OR —
p 4.0e-10
N 3,566
Large GWAS
European
About MEIS1
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
View all MEIS1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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