rs3957357

This variant is located in the GSTA1 gene.

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

omega-3 polyunsaturated fatty acid measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele G
OR 0.03
p 2.0e-38
N 450,015
Large GWAS
multi-ancestry

docosahexaenoic acid measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele G
OR 0.02
p 3.0e-18
N 450,015
Large GWAS
multi-ancestry

phospholipids in small HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele G
OR 0.02
p 1.0e-17
N 450,015
Large GWAS
multi-ancestry

polyunsaturated fatty acid measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele G
OR 0.02
p 2.0e-16
N 450,015
Large GWAS
multi-ancestry

total lipids in small HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele G
OR 0.02
p 1.0e-13
N 450,015
Large GWAS
multi-ancestry

platelet count

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele A
OR 0.04
p 1.0e-11
N 145,648
Large GWAS
East Asian

free cholesterol in small HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele G
OR 0.01
p 2.0e-11
N 450,015
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Polymorphisms of NRF2 and NRF2 target genes in urinary bladder cancer patients
AssociationN=609Edyta Reszka et al.(2014)· Journal of Cancer Research and Clinical Oncology

A case-control study of 244 urinary bladder cancer patients and 365 controls examining polymorphisms in NRF2 and five antioxidant genes (GSTM1, GSTT1, GSTA1, GSTP1, SOD2). GSTM1 null genotype was significantly associated with increased BC risk (OR 1.85, 95% CI 1.30-2.62, p=0.001), while GSTT1 null showed protective effects. Significant gene-gene interactions were identified, particularly the GSTP1×GSTT1×SOD2 variant combination (OR 0.22, 95% CI 0.09-0.56, p=0.001).

Traits studied:Urinary bladder cancer
PubMedDOIMetascience Observatory

About GSTA1

This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

View all GSTA1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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