rs402710

This is a intron variant variant in the CLPTM1L gene.

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Research that mentions this SNP (2)

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Association between CLPTM1L polymorphisms (rs402710 and rs401681) and lung cancer susceptibility: evidence from 27 case–control studies
Meta-analysisN=169,963De-ping Zhao et al.(2014)· Molecular Genetics and Genomics

Meta-analysis of 27 case-control studies (60,828 cases, 109,135 controls) examining CLPTM1L variants rs402710 and rs401681 at chromosome 5p15.33 and lung cancer susceptibility. Both SNPs showed significant increased lung cancer risk with per-allele ORs of 1.14 (95% CI 1.11-1.16, P<10^-5) for rs401681 and 1.15 (95% CI 1.12-1.19, P<10^-5) for rs402710. Associations were consistent across Caucasian and East Asian populations, histological types, and smoking status.

Traits studied:Large cell carcinomaLung adenocarcinomaLung cancerSmall cell carcinomaSquamous cell carcinoma
PubMedDOIMetascience Observatory
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Common genetic variants in TERT contribute to risk of cervical cancer in a Chinese population
Meta-analysisN=396,380Sumin Wang et al.(2012)· Molecular Carcinogenesis

This meta-analysis of 26 articles with 30,770 cases and 34,089 controls for rs402710 and 38 articles with 67,849 cases and 328,226 controls for rs401681 found that both CLPTM1L gene polymorphisms are significantly associated with decreased overall cancer risk (rs402710 allele contrast: OR = 0.88, 95% CI = 0.84-0.92; rs401681 allele contrast: OR = 0.93, 95% CI = 0.89-0.97). The association was particularly strong for lung cancer among Asians, with rs402710 showing OR = 0.85 (95% CI = 0.81-0.89) and rs401681 showing OR = 0.86 (95% CI = 0.84-0.89).

Traits studied:Basal cell carcinomaBladder cancerBreast cancerCancer risk (overall)Cervical cancerEsophageal squamous cell carcinomaGliomaLung cancerMelanomaNasopharyngeal carcinomaPancreatic cancerProstate cancerThyroid carcinoma
PubMedDOIMetascience Observatory

About CLPTM1L

The protein encoded by this gene is a membrane protein whose overexpression in cisplatin-sensitive cells causes apoptosis. Polymorphisms in this gene have been reported to increase susceptibility to several cancers, including lung, pancreatic, and breast cancers. [provided by RefSeq, Nov 2015]

View all CLPTM1L variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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