rs4151651

This variant is located in the C2;CFB gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

inflammatory bowel disease

Beecham AH et al. “Genomic Insights Into Inflammatory Bowel Disease in United States Hispanic Participants: An Ancestry-Focused Study.” Gastroenterology (2026)
Allele A
OR 2.45
p 7.0e-12
N 6,669
Large GWAS
Hispanic or Latin American

Secreted frizzled-related protein 3 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.09
p 1.0e-11
N 47,745
Large GWAS
European
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ClinVar annotation

Likely Benign★★★☆
9 submitters2 publications

Complement component 2 deficiency; Macular degeneration; Atypical hemolytic-uremic syndrome with B factor anomaly; not provided; Atypical hemolytic-uremic syndrome; CFB-related disorder; not specified

View on ClinVar →

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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