rs4227
This is a regulatory region variant variant in the SOX15 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
sex hormone-binding globulin measurement
Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele T
OR 0.23
p —
N 322,484
Major Consortium StudyLarge GWAS
multi-ancestry
testosterone measurement
Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele T
OR 0.09
p 2.0e-217
N 322,594
Major Consortium StudyLarge GWAS
multi-ancestry
Pott J et al. “Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease.” The Journal of Clinical Endocrinology and Metabolism 104(11):5008-5023 (2019)
Allele T
OR 0.07
p 3.0e-8
N 7,643
Large GWAS
European
alkaline phosphatase measurement
Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele T
OR 0.02
p 4.0e-17
N 355,891
Major Consortium StudyLarge GWAS
multi-ancestry
HbA1c measurement
Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele T
OR 0.02
p 2.0e-10
N 338,919
Major Consortium StudyLarge GWAS
multi-ancestry
IGA glomerulonephritis
Yu XQ et al. “A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.” Nature Genetics 44(2):178-82 (2011)
Allele G
OR 1.23
p 4.0e-10
N 5,704
Large GWAS
East Asian
IGF-1 measurement
Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele T
OR 0.02
p 3.0e-9
N 353,824
Major Consortium StudyLarge GWAS
multi-ancestry
▶ClinVar annotation
About SOX15
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]
View all SOX15 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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