rs4256980

This variant is located in the TRIM66 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)
Allele C
OR 0.02
p 9.0e-29
N 806,834
Meta-analysisLarge GWAS
European
Locke AE et al. “Genetic studies of body mass index yield new insights for obesity biology.” Nature 518(7538):197-206 (2015)
Allele C
OR 0.02
p 2.0e-8
N 238,944
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Influence of genetic variants associated with body mass index on eating behavior in childhood
AssociationN=3,179Claire Monnereau et al.(2017)· Obesity

In a population-based cohort of 3,179 children, the study tested two weighted genetic risk scores based on 15 childhood and 97 adult BMI-associated SNPs, plus ten individual appetite/satiety SNPs, for association with eating behavior measures. The 97 SNP adult BMI risk score was nominally associated with lower satiety responsiveness (β: -0.007 SD, 95% CI -0.013, 0.000), while individual SNPs rs11030104 (BDNF) and rs10733682 (LMX1B) showed nominal associations with reduced satiety responsiveness (β: -0.057 to -0.087 SD). Overall, findings do not strongly support that BMI-associated SNPs influence eating behavior at this young age.

Traits studied:Body mass index (BMI)Enjoyment of foodFood fussinessFood responsivenessSatiety responsivenessSlowness in eating
PubMedDOIMetascience Observatory

About TRIM66

Predicted to enable chromatin binding activity; identical protein binding activity; and zinc ion binding activity. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

View all TRIM66 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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