rs4304634

This is a intron variant variant in the WARS2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

pericardial fat amount

Salih A et al. “Genome-Wide Association Study of Pericardial Fat Area in 28 161 UK Biobank Participants.” Journal of the American Heart Association 12(21):e030661 (2023)

Allele T

OR 0.01

p 2.0e-8

N 18,774

Major Consortium StudyLarge GWAS

European

About WARS2

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

View all WARS2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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