rs4325816

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

multiple myeloma

Went M et al. “Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.” Nature Communications 9(1):3707 (2018)
Allele T
OR 1.12
p 7.0e-9
N 249,665
Large GWAS
European

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele C
OR 0.02
p 5.0e-11
N 455,180
Large GWAS
Hispanic or Latin American
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Research that mentions this SNP (1)

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Suggestion of GLYAT gene underlying variation of bone size and body lean mass as revealed by a bivariate genome-wide association study
AssociationN=3,913Yan-Fang Guo et al.(2013)· Human Genetics

A bivariate GWAS of ~690,000 SNPs in 1,627 Han Chinese and 2,286 US Caucasians identified 14 SNPs associated with both appendicular lean mass and bone size phenotypes. Three SNPs in the GLYAT gene region (rs2507838, rs7116722, rs11826261) were replicated across populations with meta-analysis p-values of 1.68×10^-8 to 7.94×10^-8 for lean mass-appendicular bone size associations, supporting GLYAT's role in co-regulating bone and muscle development through glucose metabolism.

Traits studied:Appendicular lean massBone size phenotypes (hip bone size, appendicular bone size)Muscle massOsteoporosisSarcopenia
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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