rs438811

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GWAS Catalog Trait Associations (52)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

protein MENT measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele T

OR 0.56

p —

N 10,708

Large GWAS

European

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)

Allele T

OR 0.35

p 8.0e-34

N 3,301

Large GWAS

European

protein S100-A13 measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele T

OR 1.17

p —

N 10,708

Large GWAS

European

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)

Allele T

OR —

β 1.240

p —

N 3,301

Large GWAS

European

Alzheimer disease

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele T

OR 0.10

p 2.0e-308

N 640,258

Large GWAS

European

Willett JDS et al. “Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 21(2):e14592 (2025)

Allele T

OR —

p 9.0e-161

N 27,907

Large GWAS

European, African unspecified, Hispanic or Latin American, Asian unspecified, NR

Alzheimer's disease biomarker measurement

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele T

OR 0.08

p 8.0e-254

N 568,836

Large GWAS

European

CUB and zona pellucida-like domain-containing protein 1 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)

Allele T

OR —

β 0.820

p 4.0e-230

N 3,301

Large GWAS

European

quinone oxidoreductase-like protein 1 measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele T

OR 0.47

p 3.0e-211

N 10,708

Large GWAS

European

triglyceride measurement

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele T

OR 0.13

p 6.0e-187

N 153,950

Large GWAS

East Asian

Hoffmann TJ et al. “A large electronic-health-record-based genome-wide study of serum lipids.” Nature Genetics 50(3):401-413 (2018)

Allele T

OR —

β 0.091

p 1.0e-69

N 94,674

Large GWAS

multi-ancestry

Surakka I et al. “The impact of low-frequency and rare variants on lipid levels.” Nature Genetics 47(6):589-97 (2015)

Allele T

OR 0.10

p 9.0e-37

N 62,166

Large GWAS

European

Lee SB et al. “Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease.” Biomedicines 10(7) (2022)

Allele T

OR 8.64

p 4.0e-59

N 58,701

Large GWAS

East Asian

Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)

Allele T

OR 0.09

p 5.0e-18

N 48,057

Large GWAS

Hispanic or Latin American

Jacobs BM et al. “Genetic architecture of routinely acquired blood tests in a British South Asian cohort.” Nature Communications 15(1):8929 (2024)

Allele T

OR 0.15

p 3.0e-46

N 38,000

Large GWAS

South Asian

Ibi D et al. “Genome-Wide Association Study of the Postprandial Triglyceride Response Yields Common Genetic Variation in LIPC (Hepatic Lipase).” Circulation. Genomic and Precision Medicine 13(4):e002693 (2020)

Allele T

OR 0.15

p 7.0e-13

N 5,630

Large GWAS

Alzheimer disease, family history of Alzheimer’s disease

Allele T

OR —

p 3.0e-164

N 404,467

Large GWAS

multi-ancestry

dermokine measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele T

OR 0.34

p 5.0e-116

N 10,708

Large GWAS

European

HDL cholesterol change measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele T

OR 0.04

p 8.0e-79

N 450,015

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs438811

GWAS Catalog Trait Associations (52)

protein MENT measurement

protein S100-A13 measurement

Alzheimer disease

Alzheimer's disease biomarker measurement

CUB and zona pellucida-like domain-containing protein 1 measurement

quinone oxidoreductase-like protein 1 measurement

triglyceride measurement

Alzheimer disease, family history of Alzheimer’s disease

dermokine measurement

HDL cholesterol change measurement

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