rs4396807

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

brain attribute

van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)
Allele C
OR 11.68
p 2.0e-31
N 33,748
Large GWAS
European

cortical thickness

van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)
Allele C
OR 9.65
p 5.0e-22
N 33,748
Large GWAS
European

brain connectivity attribute

Sha Z et al. “Genetic architecture of the white matter connectome of the human brain.” Science Advances 9(7):eadd2870 (2023)
Allele G
OR 7.26
p 4.0e-13
N 30,810
Large GWAS
European

mathematical ability

Lee JJ et al. “Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.” Nature Genetics 50(8):1112-1121 (2018)
Allele C
OR 0.01
p 1.0e-10
N 670,471
Large GWAS
European

brain physiology trait

Ran L et al. “Genome-wide and phenome-wide studies provided insights into brain glymphatic system function and its clinical associations.” Science Advances 11(3):eadr4606 (2025)
Allele C
OR 0.01
p 3.0e-8
N 31,629
Large GWAS
European

intelligence

Savage JE et al. “Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.” Nature Genetics 50(7):912-919 (2018)
Allele C
OR 5.51
p 4.0e-8
N 269,867
Meta-analysisLarge GWAS
European

neuroimaging measurement

Fu J et al. “Cross-ancestry genome-wide association studies of brain imaging phenotypes.” Nature Genetics 56(6):1110-1120 (2024)
Allele C
OR 0.10
p 5.0e-9
N 7,058
Large GWAS
East Asian

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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