rs442495

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Alzheimer disease, diastolic blood pressure

Bone WP et al. “Multi-trait association studies discover pleiotropic loci between Alzheimer's disease and cardiometabolic traits.” Alzheimer's Research & Therapy 13(1):34 (2021)

Allele T

OR —

p 2.0e-10

N 1,462,121

Large GWAS

Alzheimer disease

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)

Allele C

OR 0.01

p 8.0e-10

N 1,212,859

Large GWAS

European

Alzheimer disease, family history of Alzheimer’s disease

Jansen IE et al. “Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.” Nature Genetics 51(3):404-413 (2019)

Allele C

OR 6.07

p 1.0e-9

N 455,258

Meta-analysisLarge GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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