rs4478858
This variant is located in the SERINC2 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
alcohol dependence
▶Research that mentions this SNP (1)
▶The genetics of alcohol dependence: Twin and SNP‐based heritability, and genome‐wide association study based on AUDIT scoresAssociationN=7,842Hamdi Mbarek et al.(2015)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
This genome-wide association study investigated the genetic basis of alcohol dependence (AD) in 7,842 Dutch participants using the AUDIT screening measure. Twin-based heritability was estimated at 60% (95% CI: 55-69%) and common SNPs explained 33% of this heritability. The GWAS identified four suggestive loci (4q34.1, 2p16.1, 6q25.3, 7p14.1) with the strongest association at rs55768019 (P=7.58×10⁻⁷, OR=0.80). Replication confirmed known AD variants: rs1229984 in ADH1B (P=1.58×10⁻⁴, OR=1.77) and rs7119734 in DSCAML1 (P=7.5×10⁻³, OR=1.16).
About SERINC2
Enables phospholipid scramblase activity. Involved in plasma membrane phospholipid scrambling. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all SERINC2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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