rs4487645

This variant is located in the DNAH11 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

multiple myeloma

Duran-Lozano L et al. “Germline variants at SOHLH2 influence multiple myeloma risk.” Blood Cancer Journal 11(4):76 (2021)
Allele C
OR 1.26
p 5.0e-15
N 350,263
Large GWAS
European
Weinhold N et al. “The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.” Nature Genetics 45(5):522-525 (2013)
Allele C
OR 1.43
p 1.0e-9
N 8,966
Large GWAS
European
Broderick P et al. “Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.” Nature Genetics 44(1):58-61 (2011)
Allele C
OR 1.38
p 3.0e-14
N 7,578
Large GWAS
European

AL amyloidosis

da Silva Filho MI et al. “Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts: comparison with myeloma.” Leukemia 31(8):1735-1742 (2017)
Allele C
OR 1.35
p 2.0e-9
N 8,755
Large GWAS

About DNAH11

This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]

View all DNAH11 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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