rs45510091
▶GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
platelet volume
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.04
p 1.0e-29
N 394,642
Large GWAS
European
major depressive disorder
Howard DM et al. “Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.” Nature Neuroscience 22(3):343-352 (2019)
Allele A
OR 1.05
p 8.0e-21
N 807,553
Meta-analysisLarge GWAS
European
Als TD et al. “Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.” Nature Medicine 29(7):1832-1844 (2023)
Allele A
OR 0.04
p 5.0e-12
N 1,349,887
Large GWAS
European
insomnia
Watanabe K et al. “Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.” Nature Genetics 54(8):1125-1132 (2022)
Allele A
OR 0.01
p 2.0e-10
N 2,365,010
Meta-analysisLarge GWAS
European
depressive symptom measurement
Turley P et al. “Multi-trait analysis of genome-wide association summary statistics using MTAG.” Nature Genetics 50(2):229-237 (2018)
Allele A
OR 0.03
p 3.0e-9
N 354,862
Large GWAS
European
post-traumatic stress disorder
Wendt FR et al. “Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder.” Molecular Psychiatry 27(4):2206-2215 (2022)
Allele A
OR 0.03
p 7.0e-9
N 497,803
Large GWAS
European
feeling miserable measurement
Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)
Allele A
OR 5.71
p 1.0e-8
N 376,097
Large GWAS
European
generalized anxiety disorder
Wendt FR et al. “Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder.” Molecular Psychiatry 27(4):2206-2215 (2022)
Allele A
OR 0.02
p 4.0e-8
N 489,579
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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