rs45610632

This variant is located in the BRWD3 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

angina pectoris

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele T

OR 0.05

p 2.0e-9

N 630,096

Large GWAS

multi-ancestry

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ClinVar annotation

Benign★★★☆

3 submitters1 publication

not provided; Hepatocellular carcinoma; Acute myeloid leukemia; Malignant tumor of esophagus; Uterine corpus endometrial carcinoma; Ovarian serous cystadenocarcinoma; Cholangiocarcinoma

View on ClinVar →

About BRWD3

The protein encoded by this gene contains a bromodomain and several WD repeats. It is thought to have a chromatin-modifying function, and may thus play a role in transcription. Mutations in this gene are associated with a spectrum of cognitive disabilities and X-linked macrocephaly. This gene is also associated with translocations in patients with B-cell chronic lymphocytic leukemia. [provided by RefSeq, Jul 2017]

View all BRWD3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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