rs4561508

This is a intron variant variant in the TNFRSF13B gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

albumin:globulin ratio measurement

Hong KW et al. “Genome-wide association study of serum albumin:globulin ratio in Korean populations.” Journal of Human Genetics 58(3):174-7 (2013)
Allele T
OR 0.03
p 8.0e-24
N 4,637
Large GWAS
East Asian

total blood protein measurement

Choe EK et al. “Leveraging deep phenotyping from health check-up cohort with 10,000 Korean individuals for phenome-wide association study of 136 traits.” Scientific Reports 12(1):1930 (2022)
Allele T
OR —
β 0.066
p 2.0e-23
N 9,664
Large GWAS
East Asian
Franceschini N et al. “Discovery and fine mapping of serum protein loci through transethnic meta-analysis.” American Journal of Human Genetics 91(4):744-53 (2012)
Allele T
OR 0.04
p 1.0e-9
N 35,707
Meta-analysisLarge GWAS
multi-ancestry

level of immunoglobulin lambda constant 2 (human) in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.09
p 3.0e-21
N 47,745
Large GWAS
European

N-glycan measurement

Sharapov S et al. “A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins.” Nature Communications 16(1):5525 (2025)
Allele C
OR 0.17
p 2.0e-13
N 10,172
Large GWAS
European

free cholesterol in small HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele T
OR 0.02
p 6.0e-11
N 450,015
Large GWAS
multi-ancestry

About TNFRSF13B

The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

View all TNFRSF13B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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