rs4574025

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

allergic disease

Ferreira MAR et al. “Age-of-onset information helps identify 76 genetic variants associated with allergic disease.” Plos Genetics 16(6):e1008725 (2020)
Allele T
OR 0.03
p 2.0e-14
N 477,968
Large GWAS
European
Ferreira MA et al. “Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.” Nature Genetics 49(12):1752-1757 (2017)
Allele T
OR 1.03
p 7.0e-9
N 360,838
Large GWAS
European

allergic disease, age at onset

Ferreira MAR et al. “Age-of-onset information helps identify 76 genetic variants associated with allergic disease.” Plos Genetics 16(6):e1008725 (2020)
Allele T
OR 0.03
p 3.0e-14
N 117,130
Large GWAS
European

Myasthenia gravis

Chia R et al. “Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study.” Proceedings of the National Academy of Sciences of the United States of America 119(5) (2022)
Allele C
OR 1.33
p 7.0e-14
N 38,243
Large GWAS
European

hypothyroidism

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)
Allele T
OR 0.02
p 6.0e-12
N 2,444,128
Large GWAS
multi-ancestry

asthma

Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)
Allele T
OR 0.87
p 2.0e-10
N 37,846
Large GWAS
European

atopic eczema

Budu-Aggrey A et al. “European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.” Nature Communications 14(1):6172 (2023)
Allele T
OR —
p 7.0e-10
N 1,086,394
Meta-analysisLarge GWAS
multi-ancestry

asthma, age at onset

Ferreira MAR et al. “Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.” American Journal of Human Genetics 104(4):665-684 (2019)
Allele T
OR 1.06
p 4.0e-9
N 28,835
Large GWAS
European

childhood onset asthma

Pividori M et al. “Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.” The Lancet. Respiratory Medicine 7(6):509-522 (2019)
Allele T
OR 1.09
p 9.0e-9
N 327,670
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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