rs4611812
This is a intron variant variant in the ADAMTS9-AS2 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
diabetes mellitus
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.04
p 2.0e-11
N 404,034
Major Consortium StudyLarge GWAS
multi-ancestry
migraine disorder, glucose measurement
Islam MR et al. “Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin.” Human Genetics 142(8):1149-1172 (2023)
Allele T
OR 0.99
p 2.0e-10
N 1,240,100
Large GWAS
European
blood glucose amount
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele T
OR 0.01
p 2.0e-9
N 928,679
Large GWAS
multi-ancestry
carotid artery thickness
Yeung MW et al. “Twenty-Five Novel Loci for Carotid Intima-Media Thickness: A Genome-Wide Association Study in >45 000 Individuals and Meta-Analysis of >100 000 Individuals.” Arteriosclerosis, Thrombosis, and Vascular Biology 42(4):484-501 (2022)
Allele C
OR 0.04
p 4.0e-9
N 45,185
Meta-analysisLarge GWAS
multi-ancestry
Headache, glucose measurement
Islam MR et al. “Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin.” Human Genetics 142(8):1149-1172 (2023)
Allele T
OR 0.99
p 4.0e-9
N 786,347
Large GWAS
European
HbA1c measurement
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.02
p 4.0e-12
N 492,283
Major Consortium StudyLarge GWAS
multi-ancestry
About ADAMTS9-AS2
Implicated in diabetic retinopathy. [provided by Alliance of Genome Resources, Jul 2025]
View all ADAMTS9-AS2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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