rs4625

This variant is located in the DAG1 gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glomerular filtration rate

Wuttke M et al. “A catalog of genetic loci associated with kidney function from analyses of a million individuals.” Nature Genetics 51(6):957-972 (2019)

Allele A

OR 0.00

p 1.0e-12

N 765,348

Large GWAS

multi-ancestry

autoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis

Li YR et al. “Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.” Nature Medicine 21(9):1018-27 (2015)

Allele G

OR —

p 8.0e-11

N 16,754

Meta-analysisLarge GWAS

European

feeling "fed-up" measurement

Nagel M et al. “Item-level analyses reveal genetic heterogeneity in neuroticism.” Nature Communications 9(1):905 (2018)

Allele A

OR 6.43

p 1.0e-10

N 374,971

Large GWAS

European

mood disorder, major depressive disorder

Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)

Allele G

OR 0.02

p 4.0e-10

N 357,957

Meta-analysisLarge GWAS

European

taste liking measurement

May-Wilson S et al. “Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits.” Nature Communications 13(1):2743 (2022)

Allele G

OR 0.02

p 2.0e-9

N 148,801

Large GWAS

European

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ClinVar annotation

not_provided

1 submitter

View on ClinVar →

About DAG1

This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]

rs4625

GWAS Catalog Trait Associations (5)

glomerular filtration rate

autoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis

feeling "fed-up" measurement

mood disorder, major depressive disorder

taste liking measurement

ClinVar annotation

About DAG1

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