rs4654925
This variant is located in the OTUD3 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
ulcerative colitis
Franke A et al. “Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).” Nature Genetics 42(4):292-4 (2010)
Allele G
OR 1.41
p 9.0e-22
N 2,746
Large GWAS
European
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.21
p 8.0e-13
N 394,626
Large GWAS
European
About OTUD3
Enables cysteine-type deubiquitinase activity. Involved in cellular response to nutrient levels and protein deubiquitination. Acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; protein deubiquitination; and protein stabilization. Located in cytoplasm. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
View all OTUD3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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