rs4656345

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

QT interval

Arking DE et al. “Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.” Nature Genetics 46(8):826-36 (2014)
Allele A
OR 4.73
p 1.0e-19
N 71,061
Large GWAS
European
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Research that mentions this SNP (1)

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NOS1AP variant associated with incidence of type 2 diabetes in calcium channel blocker users in the Atherosclerosis Risk in Communities (ARIC) study
AssociationN=11,945Chu AY et al.(2010)· Diabetologia

In the ARIC study of 9,221 white and 2,724 African-American participants over 9 years of follow-up, rs10494366 in NOS1AP was validated as associated with reduced incidence of type 2 diabetes in calcium channel blocker (CCB) users (HR 0.57, 95% CI 0.35-0.92, p=0.016). The G allele was also associated with lower fasting glucose levels (p=0.037) in CCB users, and the association remained significant in time-dependent analysis (HR 0.70, 95% CI 0.49-0.99, p=0.036). No other NOS1AP variants showed significant associations after multiple testing correction.

Traits studied:Fasting glucoseQT intervalType 2 diabetes
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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