rs465983

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GWAS Catalog Trait Associations (10)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

BMI-adjusted fasting blood insulin measurement

Downie CG et al. “Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.” Diabetologia 65(3):477-489 (2022)
Allele A
OR 0.06
p 3.0e-16
N 48,395
Large GWAS
multi-ancestry

body composition measurement

Wu Z et al. “Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk.” Nature Communications 16(1):7490 (2025)
Allele G
OR 0.06
p 2.0e-14
N 39,172
Large GWAS
European

glucose measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)
Allele G
OR 0.02
p 3.0e-12
N 450,015
Large GWAS
multi-ancestry

appendicular lean mass

Pei YF et al. “The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study.” Communications Biology 3(1):608 (2020)
Allele A
OR 0.02
p 5.0e-12
N 450,243
Major Consortium StudyLarge GWAS
European

HbA1c measurement

Downie CG et al. “Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.” Diabetologia 65(3):477-489 (2022)
Allele A
OR 0.07
p 1.0e-9
N 9,228
Large GWAS
European

BMI-adjusted hip circumference

Christakoudi S et al. “GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.” Scientific Reports 11(1):10688 (2021)
Allele G
OR 0.02
p 2.0e-9
N 219,872
Major Consortium StudyLarge GWAS
European

BMI-adjusted waist circumference

Christakoudi S et al. “GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.” Scientific Reports 11(1):10688 (2021)
Allele G
OR 0.02
p 5.0e-10
N 219,872
Major Consortium StudyLarge GWAS
European

BMI-adjusted waist-hip ratio

Christakoudi S et al. “GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.” Scientific Reports 11(1):10688 (2021)
Allele G
OR 0.04
p 5.0e-30
N 186,825
Major Consortium StudyLarge GWAS
European

body fat distribution

Rask-Andersen M et al. “Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.” Nature Communications 10(1):339 (2019)
Allele G
OR —
β 0.025
p 5.0e-14
N 116,138
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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