rs4671328

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GWAS Catalog Trait Associations (14)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body mass index

Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)

Allele G

OR 0.02

p 3.0e-48

N 1,122,049

Large GWAS

European

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)

Allele G

OR 0.02

p 3.0e-36

N 806,834

Meta-analysisLarge GWAS

European

Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)

Allele G

OR 0.02

p 1.0e-34

N 694,649

Large GWAS

European

Sidorenko J et al. “Genetic architecture reconciles linkage and association studies of complex traits.” Nature Genetics 56(11):2352-2360 (2024)

Allele G

OR 0.02

p 3.0e-31

N 650,000

Large GWAS

European

Hawkes G et al. “Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.” Diabetologia 66(8):1472-1480 (2023)

Allele G

OR 0.02

p 2.0e-29

N 441,761

Large GWAS

European

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.02

p 3.0e-23

N 394,642

Large GWAS

European

Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)

Allele G

OR 0.02

p 9.0e-23

N 342,566

Large GWAS

European

Hoffmann TJ et al. “A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.” Genetics 210(2):499-515 (2018)

Allele G

OR —

β 0.024

p 5.0e-18

N 334,487

Large GWAS

multi-ancestry

Akiyama M et al. “Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.” Nature Genetics 49(10):1458-1467 (2017)

Allele G

OR 0.02

p 2.0e-15

N 158,284

Large GWAS

multi-ancestry

body height

Richardson TG et al. “Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study.” Bmj (clinical Research Ed.) 369:m1203 (2020)

Allele T

OR 0.01

p 2.0e-21

N 453,169

Large GWAS

European

body weight

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.01

p 4.0e-19

N 394,642

Large GWAS

European

fat pad mass

Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)

Allele G

OR 0.02

p 4.0e-19

N 337,196

Large GWAS

European

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.02

p 3.0e-17

N 394,642

Large GWAS

European

waist circumference

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.01

p 2.0e-14

N 394,642

Large GWAS

European

whole body water mass

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.01

p 2.0e-12

N 394,642

Large GWAS

European

non-alcoholic fatty liver disease

Du M et al. “Cross-trait genomic modeling reveals the polygenic architecture and systemic impact of MASLD.” Science Advances 12(7):eaeb5665 (2026)

Allele T

OR 0.03

p 3.0e-12

N 122,644

Large GWAS

European

triglyceride measurement

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele T

OR 0.01

p 5.0e-12

N 928,679

Large GWAS

multi-ancestry

hip circumference

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.01

p 7.0e-12

N 394,642

Large GWAS

European

lean body mass

Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)

Allele G

OR 0.01

p 3.0e-11

N 337,739

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

rs4671328

GWAS Catalog Trait Associations (14)

body mass index

body height

body weight

fat pad mass

waist circumference

whole body water mass

non-alcoholic fatty liver disease

triglyceride measurement

hip circumference

lean body mass

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