rs4682495

This variant is located in the SIDT1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate cancer

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.08

p 5.0e-19

N 367,640

Major Consortium StudyLarge GWAS

multi-ancestry

brain attribute

van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)

Allele C

OR 7.91

p 3.0e-15

N 33,748

Large GWAS

European

prostate specific antigen amount

Kachuri L et al. “Genetically adjusted PSA levels for prostate cancer screening.” Nature Medicine 29(6):1412-1423 (2023)

Allele A

OR 0.02

p 3.0e-9

N 95,768

Large GWAS

multi-ancestry

About SIDT1

The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]

View all SIDT1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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