rs4693089
This variant is located in the HELQ gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
age at menopause
Day FR et al. “Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.” Nature Genetics 47(11):1294-1303 (2015)
Allele A
OR 0.20
p 9.0e-23
N 69,626
Large GWAS
European
Stolk L et al. “Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.” Nature Genetics 44(3):260-8 (2012)
Allele A
OR 0.23
p 2.0e-19
N 38,968
Large GWAS
European
estradiol measurement
Oppenheimer H et al. “No causal links between estradiol and female's brain and mental health using Mendelian randomization.” Nature Communications 16(1):10915 (2025)
Allele G
OR 1.06
p 4.0e-10
N 207,119
Large GWAS
European
About HELQ
HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 [PubMed 11751861]).[supplied by OMIM, Mar 2008]
View all HELQ variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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