rs4746140

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

heart failure

Henry A et al. “Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.” Nature Genetics 57(4):815-828 (2025)

Allele C

OR 0.06

p 2.0e-22

N 1,968,806

Meta-analysisLarge GWAS

multi-ancestry

Enzan N et al. “Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.” Nature Communications 16(1):9680 (2025)

Allele C

OR 0.04

p 3.0e-12

N 1,672,415

Large GWAS

multi-ancestry

Levin MG et al. “Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.” Nature Communications 13(1):6914 (2022)

Allele C

OR 0.05

p 4.0e-17

N 1,665,481

Large GWAS

multi-ancestry

Shah S et al. “Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.” Nature Communications 11(1):163 (2020)

Allele C

OR 1.07

p 1.0e-9

N 977,323

Large GWAS

European

QT interval

Young WJ et al. “Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.” Nature Communications 13(1):5144 (2022)

Allele C

OR 0.02

p 5.0e-10

N 252,730

Large GWAS

European, African unspecified, Hispanic or Latin American, South East Asian, South Asian

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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