rs4746822

This is a coding sequence variant variant in the HKDC1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glucose tolerance test

Hayes MG et al. “Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.” Diabetes 62(9):3282-91 (2013)

Allele T

OR 0.28

p 1.0e-22

N 4,437

Large GWAS

multi-ancestry

blood glucose amount

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele T

OR 0.01

p 4.0e-10

N 928,679

Large GWAS

multi-ancestry

About HKDC1

This gene encodes a member of the hexokinase protein family. The encoded protein is involved in glucose metabolism, and reduced expression may be associated with gestational diabetes mellitus. High expression of this gene may also be associated with poor prognosis in hepatocarcinoma. [provided by RefSeq, Sep 2016]

View all HKDC1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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