HKDC1

hexokinase domain containing 1

Summary

This gene encodes a member of the hexokinase protein family. The encoded protein is involved in glucose metabolism, and reduced expression may be associated with gestational diabetes mellitus. High expression of this gene may also be associated with poor prognosis in hepatocarcinoma. [provided by RefSeq, Sep 2016]

Known Variants99 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs4746822	10:70,982,941	C/T	coding sequence variant	—
rs9663238	10:70,983,629	A/G	intron variant	—
rs35199395	10:70,983,936	G/C	intron variant	—
rs75405157	10:70,984,845	T/C	intron variant	—
rs2394529	10:70,985,267	G/C	regulatory region variant	—
rs139901086	10:70,987,023	C/T	—	uncertain significance
rs750989819	10:70,987,025	G/T	—	likely benign
rs372174004	10:70,987,029	C/T	—	uncertain significance
rs142379141	10:70,987,072	C/T	—	likely pathogenic
rs74138158	10:70,987,096	C/T	—	benign
rs759029504	10:70,987,101	G/A	—	uncertain significance
rs2539897956	10:70,992,543	G/A	—	likely pathogenic
rs374745925	10:70,992,574	A/C	—	uncertain significance
rs1564726619	10:70,992,594	G/T	—	likely pathogenic
rs137872948	10:70,992,617	G/C	—	uncertain significance
rs140840058	10:70,992,619	G/A	—	uncertain significance
rs752581214	10:70,992,621	C/G	—	uncertain significance
rs539903056	10:70,992,651	C/T	—	uncertain significance
rs200115968	10:70,992,652	G/A	—	uncertain significance
rs1326361327	10:70,992,654	G/A	—	uncertain significance
rs1187431635	10:70,998,886	G/C	—	uncertain significance
rs771030979	10:71,000,420	G/A	—	uncertain significance
rs756481700	10:71,000,476	C/A	—	uncertain significance
rs746967718	10:71,000,496	G/T	—	uncertain significance
rs777018497	10:71,002,976	A/G	—	uncertain significance
rs2539911413	10:71,003,009	A/T	—	uncertain significance
rs372652067	10:71,003,045	G/A	—	uncertain significance
rs143670175	10:71,003,066	C/T	—	uncertain significance
rs779545610	10:71,003,067	G/A	—	uncertain significance
rs748606620	10:71,003,078	G/A	—	uncertain significance
rs202105296	10:71,003,096	G/A	—	uncertain significance
rs2539916006	10:71,005,846	T/C	—	uncertain significance
rs763033929	10:71,005,860	T/C	—	uncertain significance
rs374482574	10:71,005,904	G/T	—	uncertain significance
rs796052175	10:71,005,960	T/A	—	likely benign
rs148723879	10:71,005,968	C/T	—	likely pathogenic
rs200034765	10:71,007,172	C/T	—	uncertain significance
rs2539918546	10:71,007,211	C/T	—	uncertain significance
rs758771292	10:71,007,229	C/T	—	uncertain significance
rs200584895	10:71,007,276	C/T	—	uncertain significance
rs144349538	10:71,007,287	G/C	—	uncertain significance
rs764742218	10:71,007,297	C/T	—	uncertain significance
rs2539918923	10:71,007,334	A/G	—	likely pathogenic
rs201518882	10:71,007,342	C/T	—	conflicting classifications of pathogenicity
rs148832840	10:71,008,190	C/T	—	likely benign
rs1039928352	10:71,008,268	G/A	—	uncertain significance
rs770704263	10:71,008,285	C/T	—	likely benign
rs552439176	10:71,008,286	G/A	—	uncertain significance
rs267602560	10:71,008,314	G/A	—	uncertain significance
rs375135631	10:71,008,325	G/A	—	uncertain significance
rs534744139	10:71,008,373	G/A	—	uncertain significance
rs2539921454	10:71,008,400	G/A	—	uncertain significance
rs759564040	10:71,008,457	T/C	—	uncertain significance
rs776482675	10:71,008,460	G/A	—	uncertain significance
rs376726432	10:71,008,473	C/T	—	uncertain significance
rs373196996	10:71,009,159	A/T	—	—
rs747047588	10:71,010,058	T/C	—	uncertain significance
rs138845753	10:71,010,079	G/T	—	uncertain significance
rs764512946	10:71,010,121	G/A	—	uncertain significance
rs1381721567	10:71,010,137	G/C	—	uncertain significance
rs755086158	10:71,010,147	A/G	—	uncertain significance
rs779866372	10:71,010,304	G/A	—	uncertain significance
rs780647583	10:71,010,316	G/T	—	uncertain significance
rs748748783	10:71,010,397	A/G	—	uncertain significance
rs146301899	10:71,016,849	G/A	—	uncertain significance
rs772860598	10:71,017,110	G/A	—	uncertain significance
rs202109020	10:71,017,116	G/A	—	uncertain significance
rs371588891	10:71,017,168	T/C	—	uncertain significance
rs1283196836	10:71,018,555	A/G	—	uncertain significance
rs753235874	10:71,018,576	G/A	—	uncertain significance
rs754159524	10:71,018,588	G/A	—	uncertain significance
rs151179698	10:71,018,589	G/A	—	uncertain significance
rs781046015	10:71,018,592	G/A	—	likely benign
rs2539936674	10:71,018,606	T/C	—	uncertain significance
rs774145826	10:71,018,631	T/A	—	uncertain significance
rs200454007	10:71,018,649	T/C	—	uncertain significance
rs777790533	10:71,018,667	G/A	—	likely benign
rs1201295597	10:71,018,672	G/A	—	uncertain significance
rs779802342	10:71,020,896	T/A	—	uncertain significance
rs2539939505	10:71,020,897	A/G	—	uncertain significance
rs373020719	10:71,020,921	A/C	—	uncertain significance
rs148886636	10:71,020,932	A/G	missense variant	—
rs759709025	10:71,020,980	C/T	—	likely pathogenic
rs774217376	10:71,020,981	G/A	—	uncertain significance
rs143285779	10:71,021,004	C/T	—	uncertain significance
rs539633142	10:71,021,005	G/A	—	uncertain significance
rs1843805763	10:71,021,037	T/A	—	uncertain significance
rs769896723	10:71,025,381	C/A	—	uncertain significance
rs774312956	10:71,025,387	G/A	—	uncertain significance
rs143547587	10:71,025,440	T/C	—	benign
rs367579140	10:71,025,451	G/A	—	uncertain significance
rs761553657	10:71,025,468	G/A	—	uncertain significance
rs369853003	10:71,025,496	A/C	—	uncertain significance
rs980685211	10:71,025,534	A/T	—	uncertain significance
rs138886817	10:71,025,545	G/C	—	benign
rs923490364	10:71,026,404	C/T	—	uncertain significance
rs2539945709	10:71,026,422	C/T	—	uncertain significance
rs148418934	10:71,026,433	T/C	—	likely benign
rs1167065899	10:71,026,491	A/G	—	uncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.