rs476348

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

left ventricular structural measurement

Ning C et al. “Genome-wide association analysis of left ventricular imaging-derived phenotypes identifies 72 risk loci and yields genetic insights into hypertrophic cardiomyopathy.” Nature Communications 14(1):7900 (2023)

Allele T

OR 0.06

p 6.0e-16

N 41,770

Large GWAS

European

Brugada syndrome

Ishikawa T et al. “Brugada syndrome in Japan and Europe: a genome-wide association study reveals shared genetic architecture and new risk loci.” European Heart Journal 45(26):2320-2332 (2024)

Allele C

OR 1.25

p 6.0e-11

N 15,395

Large GWAS

multi-ancestry

Barc J et al. “Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility.” Nature Genetics 54(3):232-239 (2022)

Allele C

OR 1.25

p 3.0e-9

N 12,821

Large GWAS

European

electrocardiography

Verweij N et al. “The Genetic Makeup of the Electrocardiogram.” Cell Systems 11(3):229-238.e5 (2020)

Allele T

OR 0.04

p 5.0e-10

N 63,706

Major Consortium StudyLarge GWAS

European, NR

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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