rs4766566

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

uric acid measurement

Nakatochi M et al. “Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.” Communications Biology 2:115 (2019)

Allele T

OR 0.06

p 7.0e-40

N 210,206

Meta-analysisLarge GWAS

multi-ancestry

coronary artery disease

Matsunaga H et al. “Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease.” Circulation. Genomic and Precision Medicine 13(3):e002670 (2020)

Allele C

OR 1.24

p 2.0e-25

N 51,442

Meta-analysisLarge GWAS

East Asian

gout

Nakayama A et al. “GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes.” Annals of the Rheumatic Diseases 76(5):869-877 (2017)

Allele T

OR 1.51

p 4.0e-20

N 2,158

Large GWAS

multi-ancestry

blood copper level

Yang W et al. “Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans.” Communications Biology 5(1):405 (2022)

Allele C

OR 0.19

p 4.0e-8

N 1,798

Large GWAS

East Asian

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Research that mentions this SNP (1)

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ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.

AssociationN=313Quillen EE et al.(2014)· American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

Genome-wide association study of alcohol dependence and related phenotypes in 313 males from extended Han Chinese pedigrees in Northern Hunan Province. ALDH2 rs671 (Glu504Lys) was identified as the major genetic determinant, with genome-wide significant associations for alcohol dependence (p=4.73×10⁻⁸), maximum drinks in 24 hours (p=1.54×10⁻¹⁶), and facial flushing response (p=4.75×10⁻²⁶). The rs671 variant explained 7.9% of AD phenotypic variation, 22.9% of maximum drinks variation, and 29.2% of flushing response variation. A previously reported candidate SNP rs10774610 in CCDC63 was confirmed but shown to result from linkage disequilibrium with ALDH2.

Traits studied:Alcohol consumption (maximum drinks in 24 hours)Alcohol dependenceFacial flushing response to alcohol

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.