rs4808199

This variant is located in the GATAD2A gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)

Allele A

OR 0.02

p 4.0e-15

N 472,730

Large GWAS

East Asian

non-alcoholic fatty liver disease

Kawaguchi T et al. “Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers.” Plos One 13(1):e0185490 (2018)

Allele A

OR 1.37

p 2.0e-8

N 8,574

Large GWAS

East Asian

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Research that mentions this SNP (1)

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Association Between Liver-Specific Gene Polymorphisms and Their Expression Levels With Nonalcoholic Fatty Liver Disease

ReviewLeon A. Adams et al.(2013)· Hepatology

A comprehensive review of the pathogenesis of non-alcoholic fatty liver disease (NAFLD) in children and adolescents, examining the evolution from the 'two-hit theory' to the 'multiple-hit model'. The paper discusses genetic factors including PNPLA3 rs738409 and GCKR rs1260326 polymorphisms, which together account for up to one-third of variability in liver fat content in obese children, along with contributions from MBOAT7, SAMM50, PARVB, TM6SF2, and other genes involved in lipid metabolism.

Traits studied:Fatty liverLiver fibrosisNon-alcoholic fatty liver disease (NAFLD)Non-alcoholic steatohepatitis (NASH)

PubMed DOI Metascience Observatory

About GATAD2A

Enables protein-macromolecule adaptor activity. Involved in chromatin remodeling and negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of NuRD complex. [provided by Alliance of Genome Resources, Jul 2025]