rs4810992

This is a upstream gene variant variant in the RNF114 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

frontotemporal dementia

Chen K et al. “Identifying risk loci for FTD and shared genetic component with ALS: A large-scale multitrait association analysis.” Neurobiology of Aging 134:28-39 (2024)

Allele A

OR 0.04

p 4.0e-9

N 12,928

Large GWAS

European

About RNF114

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol and plasma membrane. Biomarker of male infertility. [provided by Alliance of Genome Resources, Jul 2025]

View all RNF114 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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