rs4819388
This is a regulatory region variant variant in the ICOSLG gene.
▶Research that mentions this SNP (1)
▶Genetic variants associated with celiac disease and the risk for coronary artery diseaseMeta-analysisN=86,995Henning Jansen et al.(2015)· Molecular Genetics and Genomics
This meta-analysis of 22,233 CAD cases and 64,762 controls tested 41 celiac disease-associated SNPs for association with coronary artery disease (CAD). While 58.5% of celiac disease risk alleles showed positive association with CAD (OR 1.001-1.081), this was not significantly different from the 50% expected by chance (p=0.069). Only rs653178 at the SH2B3/ATXN2 locus achieved study-wide statistical significance (OR 1.081, p=2.2×10⁻⁶), likely through pleiotropic effects. The findings provide no convincing evidence that genetic variants associated with celiac disease contribute to CAD risk.
About ICOSLG
Enables identical protein binding activity and receptor ligand activity. Involved in T follicular helper cell differentiation. Located in intracellular membrane-bounded organelle. Is active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
View all ICOSLG variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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