ICOSLG

inducible T cell costimulator ligand

Summary

Enables identical protein binding activity and receptor ligand activity. Involved in T follicular helper cell differentiation. Located in intracellular membrane-bounded organelle. Is active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Known Variants223 total

rsidPosition (GRCh37)AllelesClassClinVar
rs37309838421:45,644,506G/A——
rs481938821:45,647,421T/Cregulatory region variant—
rs74605700021:45,648,918C/G—uncertain significance
rs116245361621:45,648,923G/A—likely benign
rs14256611121:45,648,941T/G—likely benign
rs55186206721:45,648,947A/G—benign
rs251783439121:45,649,518G/A—likely benign
rs13841415321:45,649,539C/T—likely benign
rs251783454921:45,649,542G/A—likely benign
rs74532100921:45,649,552C/T—likely benign
rs57203523921:45,649,596G/A—likely benign
rs75891436821:45,649,623G/A—likely benign
rs11708285121:45,649,714T/C—likely benign
rs18876101721:45,649,715G/A—likely benign
rs57003792821:45,649,782G/A—likely benign
rs20025019721:45,649,814A/T—likely benign
rs36883290521:45,649,925C/T—likely benign
rs76550605821:45,649,941G/A—likely benign
rs251783593221:45,649,946C/T—uncertain significance
rs136237061521:45,649,953C/G—likely benign
rs18645947621:45,649,954G/A—conflicting classifications of pathogenicity
rs251783600121:45,649,965C/T—uncertain significance
rs251783600721:45,649,968G/A—likely benign
rs19987873521:45,649,969G/A—conflicting classifications of pathogenicity
rs131389279021:45,649,970C/T—uncertain significance
rs19136003521:45,649,974T/C—uncertain significance
rs214633211021:45,649,976G/A—likely benign
rs214633213621:45,649,980A/G—likely benign
rs37387343121:45,651,145A/G—likely benign
rs125626753621:45,651,146T/C—likely benign
rs76206921121:45,651,147A/G—likely benign
rs75086315621:45,651,154C/T—likely benign
rs57122724821:45,651,155G/A—likely benign
rs37684076421:45,651,159C/T—conflicting classifications of pathogenicity
rs75700298721:45,651,172T/C—uncertain significance
rs78123342021:45,651,173G/A—likely benign
rs76967108221:45,651,182G/T—uncertain significance
rs37113716321:45,651,186C/T—uncertain significance
rs214633541121:45,651,188G/A—likely benign
rs251783897321:45,651,193T/C—uncertain significance
rs123114811521:45,651,200C/G—uncertain significance
rs37400920421:45,651,210G/A—uncertain significance
rs75226604721:45,651,215C/T—likely benign
rs20079328221:45,651,216G/A—uncertain significance
rs119385148121:45,651,217C/A—uncertain significance
rs37021123621:45,651,220C/T—uncertain significance
rs37363090721:45,651,221G/A—likely benign
rs87907589821:45,651,224C/G—likely benign
rs78087252521:45,651,233G/A—likely benign
rs214633565721:45,651,237A/G—uncertain significance
rs251783928221:45,651,242A/G—likely benign
rs77991024821:45,651,243G/T—uncertain significance
rs14478090721:45,651,257C/A—likely benign
rs76858586921:45,651,258G/A—uncertain significance
rs53351097121:45,651,263C/T—likely benign
rs77229423521:45,651,264G/A—conflicting classifications of pathogenicity
rs119589052021:45,651,265C/T—uncertain significance
rs77371275221:45,651,266G/A—likely benign
rs20179168521:45,651,274C/T—uncertain significance
rs214633585821:45,651,275G/A—likely benign
rs118517369721:45,651,277C/G—uncertain significance
rs55472153421:45,651,278G/A—benign
rs204004920621:45,651,310T/C—uncertain significance
rs251783954521:45,651,312T/C—uncertain significance
rs75689070221:45,651,316C/T—uncertain significance
rs56923094821:45,651,317G/A—likely benign
rs20146282221:45,651,319T/C—uncertain significance
rs75023339121:45,651,334G/A—likely benign
rs251783964221:45,651,340G/A—likely benign
rs37261926021:45,655,135C/T—likely benign
rs120989019921:45,655,136G/A—likely benign
rs75004473521:45,655,141C/T—likely benign
rs36913761821:45,655,142G/A—likely benign
rs92544335521:45,655,144C/T—likely benign
rs52858052921:45,655,145G/A—likely benign
rs76628951021:45,655,147G/A—likely benign
rs251784533821:45,655,165G/C—likely benign
rs105529152021:45,655,167C/T—conflicting classifications of pathogenicity
rs76618349821:45,655,168G/A—likely benign
rs76854548021:45,655,181T/C—uncertain significance
rs127664472921:45,655,183C/G—uncertain significance
rs251784542221:45,655,184T/C—uncertain significance
rs77884809021:45,655,195G/C—uncertain significance
rs214634207821:45,655,202A/G—uncertain significance
rs77818408021:45,655,203T/C—uncertain significance
rs146702799721:45,655,221C/T—uncertain significance
rs37352837421:45,655,222G/A—likely benign
rs77605455521:45,655,228G/T—likely benign
rs77660496621:45,655,232C/T—uncertain significance
rs77154721321:45,655,233G/A—uncertain significance
rs14089476821:45,655,236C/T—conflicting classifications of pathogenicity
rs14309774321:45,655,237G/A—likely benign
rs125106818521:45,655,238A/G—uncertain significance
rs251784568421:45,655,240C/G—uncertain significance
rs53319373121:45,655,248C/T—uncertain significance
rs57818847521:45,655,258G/A—likely benign
rs5610592921:45,655,271C/T—uncertain significance
rs76429513821:45,655,272G/A—uncertain significance
rs53732436021:45,655,287C/T—uncertain significance
rs75649832521:45,655,288G/T—likely benign

Showing 100 of 223 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.