rs4846913

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GWAS Catalog Trait Associations (10)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

blood protein amount

Gudjonsson A et al. “A genome-wide association study of serum proteins reveals shared loci with common diseases.” Nature Communications 13(1):480 (2022)
Allele C
OR 0.30
p 3.0e-59
N 5,365
Large GWAS
European

apolipoprotein C measurement

Naber A et al. “Apolipoprotein-CIII O-Glycosylation, a Link between GALNT2 and Plasma Lipids.” International Journal of Molecular Sciences 24(19) (2023)
Allele A
OR 0.20
p 1.0e-35
N 2,318
Large GWAS

triglycerides:total lipids ratio, blood VLDL cholesterol amount

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele A
OR 0.04
p 7.0e-26
N 136,016
Large GWAS
multi-ancestry

cholesterol:total lipids ratio, blood VLDL cholesterol amount

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele A
OR 0.04
p 2.0e-21
N 136,016
Large GWAS
multi-ancestry

social deprivation, triglyceride measurement

Bentley AR et al. “Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.” Translational Psychiatry 15(1):207 (2025)
Allele A
OR —
β 0.011
p 1.0e-13
N 105,888
Large GWAS
multi-ancestry

cholesteryl esters:total lipids ratio, blood VLDL cholesterol amount

Karjalainen MK et al. “Genome-wide characterization of circulating metabolic biomarkers.” Nature 628(8006):130-138 (2024)
Allele A
OR 0.04
p 2.0e-20
N 136,016
Large GWAS
multi-ancestry

high density lipoprotein cholesterol measurement

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele A
OR 0.04
p 7.0e-20
N 153,950
Large GWAS
East Asian
Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele A
OR 0.04
p 4.0e-10
N 146,492
Large GWAS
East Asian

triglyceride measurement

Kim YJ et al. “The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians.” Nature Communications 13(1):6642 (2022)
Allele A
OR 0.03
p 9.0e-15
N 288,127
Large GWAS
East Asian
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele A
OR 0.04
p 2.0e-22
N 153,950
Large GWAS
East Asian
Graham SE et al. “The power of genetic diversity in genome-wide association studies of lipids.” Nature 600(7890):675-679 (2021)
Allele A
OR 0.05
p 9.0e-13
N 99,432
Large GWAS
African American or Afro-Caribbean, African unspecified

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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