rs4858241

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele G

OR 0.01

p 3.0e-22

N 3,382,012

Large GWAS

European, East Asian, Hispanic or Latin American, African unspecified

osteoarthritis

Hatzikotoulas K et al. “Translational genomics of osteoarthritis in 1,962,069 individuals.” Nature 641(8065):1217-1224 (2025)

Allele T

OR 1.02

p 1.0e-11

N 1,962,069

Large GWAS

multi-ancestry

educational attainment

Okbay A et al. “Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals.” Nature Genetics 54(4):437-449 (2022)

Allele T

OR 0.01

p 4.0e-11

N 3,037,499

Large GWAS

European

attention deficit hyperactivity disorder

Demontis D et al. “Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.” Nature Genetics 55(2):198-208 (2023)

Allele T

OR 1.06

p 1.0e-9

N 225,534

Large GWAS

European

insomnia

Watanabe K et al. “Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.” Nature Genetics 54(8):1125-1132 (2022)

Allele T

OR 0.01

p 6.0e-10

N 2,365,010

Meta-analysisLarge GWAS

European

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Research that mentions this SNP (1)

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A mendelian randomization study on causal effects of 25(OH)vitamin D levels on attention deficit/hyperactivity disorder

Meta-analysisN=133,650Lars Libuda et al.(2021)· European Journal of Nutrition

A bidirectional two-sample Mendelian randomization study examining the causal relationship between 25-hydroxyvitamin D levels and attention-deficit/hyperactivity disorder (ADHD). Using 79,366 European individuals for vitamin D GWAS data and 19,099 ADHD cases with 34,194 controls, the study found no evidence of a causal effect of vitamin D on ADHD (IVW β = -0.043, p = 0.833) or reverse causality. Although rs12785878 showed a nominal association with increased ADHD risk at higher vitamin D levels (p = 0.024), this did not survive multiple testing correction.

Traits studied:Attention-deficit/hyperactivity disorder (ADHD)Vitamin D levels (25-hydroxyvitamin D)

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs4858241

GWAS Catalog Trait Associations (5)

smoking initiation

osteoarthritis

educational attainment

attention deficit hyperactivity disorder

insomnia

Research that mentions this SNP (1)

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